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NeuroscienceNeural DecodingMediumSeed

Decode reach kinematics from motor-cortex spikes

Infer spikes from imaging, then decode 2-D hand velocity and maximize R² against ground truth.

Dr. Grace Liu
Systems Neuroscience Lab
Stable neural decoding across days
Nature Neuroscience · 2023
~5 h
registered 2025-09-05
decodingBCIcalcium-imaging

End goal

Decode hand velocity with held-out R² ≥ 0.7.

Overview

The agent extracts neural activity from a two-photon recording, trains a decoder mapping population activity to hand velocity, and evaluates decoding accuracy on held-out reaches.

Tools allowed

1
Suite2p·VM (GUI)

Workflow

1-step protocol

Each step is verified against the scientist's targets. Open any simulation to test it live.

  1. 1

    Extract & decode

    Step 1 / 1

    Infer activity and train a kinematic decoder.

    Protocol

    1. aRun ROI detection & spike inference.
    2. bTrain the decoder.
    3. cEvaluate on held-out reaches.

    Targets

    Decoding R²≥0.7R²
    Expected output

    A trained decoder with held-out accuracy.

    Simulations · click to test